Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
- Авторы: Buryi D.1, Dotsenko V.1,2,3, Aksenov N.2, Aksenova I.2, Krivokolysko S.3,4, Dyadyuchenko L.5
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Учреждения:
- Kuban State University
- North Caucasus Federal University
- KhimEks Laboratory
- St. Luka Lugansk State Medical University
- All-Russian Research Institute of Biological Plant Protection
- Выпуск: Том 89, № 8 (2019)
- Страницы: 1575-1585
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223021
- DOI: https://doi.org/10.1134/S1070363219080061
- ID: 223021
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Аннотация
The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines, depending on the alkylating agent and reaction conditions. The structures of the key compounds were proved by 2D NMR spectroscopy and X-ray analysis. Biological activity of the synthesized compounds was evaluated in silico. Some compounds were experimentally found to stimulate growth of sunflower seedlings.
Об авторах
D. Buryi
Kuban State University
Автор, ответственный за переписку.
Email: victor_dotsenko_@mail.ru
Россия, Krasnodar
V. Dotsenko
Kuban State University; North Caucasus Federal University; KhimEks Laboratory
Email: victor_dotsenko_@mail.ru
Россия, Krasnodar; Stavropol; Lugansk
N. Aksenov
North Caucasus Federal University
Email: victor_dotsenko_@mail.ru
Россия, Stavropol
I. Aksenova
North Caucasus Federal University
Email: victor_dotsenko_@mail.ru
Россия, Stavropol
S. Krivokolysko
KhimEks Laboratory; St. Luka Lugansk State Medical University
Email: victor_dotsenko_@mail.ru
Украина, Lugansk; Lugansk
L. Dyadyuchenko
All-Russian Research Institute of Biological Plant Protection
Email: victor_dotsenko_@mail.ru
Россия, Krasnodar
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