Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
- Авторлар: Buryi D.1, Dotsenko V.1,2,3, Aksenov N.2, Aksenova I.2, Krivokolysko S.3,4, Dyadyuchenko L.5
-
Мекемелер:
- Kuban State University
- North Caucasus Federal University
- KhimEks Laboratory
- St. Luka Lugansk State Medical University
- All-Russian Research Institute of Biological Plant Protection
- Шығарылым: Том 89, № 8 (2019)
- Беттер: 1575-1585
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223021
- DOI: https://doi.org/10.1134/S1070363219080061
- ID: 223021
Дәйексөз келтіру
Аннотация
The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines, depending on the alkylating agent and reaction conditions. The structures of the key compounds were proved by 2D NMR spectroscopy and X-ray analysis. Biological activity of the synthesized compounds was evaluated in silico. Some compounds were experimentally found to stimulate growth of sunflower seedlings.
Авторлар туралы
D. Buryi
Kuban State University
Хат алмасуға жауапты Автор.
Email: victor_dotsenko_@mail.ru
Ресей, Krasnodar
V. Dotsenko
Kuban State University; North Caucasus Federal University; KhimEks Laboratory
Email: victor_dotsenko_@mail.ru
Ресей, Krasnodar; Stavropol; Lugansk
N. Aksenov
North Caucasus Federal University
Email: victor_dotsenko_@mail.ru
Ресей, Stavropol
I. Aksenova
North Caucasus Federal University
Email: victor_dotsenko_@mail.ru
Ресей, Stavropol
S. Krivokolysko
KhimEks Laboratory; St. Luka Lugansk State Medical University
Email: victor_dotsenko_@mail.ru
Украина, Lugansk; Lugansk
L. Dyadyuchenko
All-Russian Research Institute of Biological Plant Protection
Email: victor_dotsenko_@mail.ru
Ресей, Krasnodar
![](/img/style/loading.gif)