Pyrazine-2-carbohydrazone of Pyridoxal 5′-Phosphate: Synthesis, Stability, Formation Kinetics, and Interaction with DNA
- Авторы: Gamov G.1, Zavalishin M.1, Aleksandriyskii V.1, Sharnin V.1
-
Учреждения:
- Ivanovo State University of Chemistry and Technology
- Выпуск: Том 89, № 2 (2019)
- Страницы: 230-235
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222744
- DOI: https://doi.org/10.1134/S1070363219020105
- ID: 222744
Цитировать
Аннотация
(5-Hydroxy-6-methyl-4-{(E)-[2-oxo-2-(pyrazin-2-yl)ethyl]hydrazinylidenemethyl}pyridin-3-yl)- methyl phosphate has been synthesized via the interaction of pyridoxal-5-phosphate and pyrazin-2- carbohydrazide. Its stability constants in an aqueous solution at pH = 1.9, 6.6, 7.0, and 7.4 have been determined. The kinetics of formation and hydrolysis of the hydrazone has been studied, and rate constants of the direct and reverse reactions have been calculated from the electronic absorption spectroscopy data. The interaction of the obtained hydrazone and its Cu(II) complex with calf thymus DNA has been investigated.
Ключевые слова
Об авторах
G. Gamov
Ivanovo State University of Chemistry and Technology
Автор, ответственный за переписку.
Email: oxt705@isuct.ru
Россия, Sheremetevskii pr. 7, Ivanovo, 153000
M. Zavalishin
Ivanovo State University of Chemistry and Technology
Email: oxt705@isuct.ru
Россия, Sheremetevskii pr. 7, Ivanovo, 153000
V. Aleksandriyskii
Ivanovo State University of Chemistry and Technology
Email: oxt705@isuct.ru
Россия, Sheremetevskii pr. 7, Ivanovo, 153000
V. Sharnin
Ivanovo State University of Chemistry and Technology
Email: oxt705@isuct.ru
Россия, Sheremetevskii pr. 7, Ivanovo, 153000
![](/img/style/loading.gif)