Pyrazine-2-carbohydrazone of Pyridoxal 5′-Phosphate: Synthesis, Stability, Formation Kinetics, and Interaction with DNA
- Авторлар: Gamov G.1, Zavalishin M.1, Aleksandriyskii V.1, Sharnin V.1
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Мекемелер:
- Ivanovo State University of Chemistry and Technology
- Шығарылым: Том 89, № 2 (2019)
- Беттер: 230-235
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222744
- DOI: https://doi.org/10.1134/S1070363219020105
- ID: 222744
Дәйексөз келтіру
Аннотация
(5-Hydroxy-6-methyl-4-{(E)-[2-oxo-2-(pyrazin-2-yl)ethyl]hydrazinylidenemethyl}pyridin-3-yl)- methyl phosphate has been synthesized via the interaction of pyridoxal-5-phosphate and pyrazin-2- carbohydrazide. Its stability constants in an aqueous solution at pH = 1.9, 6.6, 7.0, and 7.4 have been determined. The kinetics of formation and hydrolysis of the hydrazone has been studied, and rate constants of the direct and reverse reactions have been calculated from the electronic absorption spectroscopy data. The interaction of the obtained hydrazone and its Cu(II) complex with calf thymus DNA has been investigated.
Негізгі сөздер
Авторлар туралы
G. Gamov
Ivanovo State University of Chemistry and Technology
Хат алмасуға жауапты Автор.
Email: oxt705@isuct.ru
Ресей, Sheremetevskii pr. 7, Ivanovo, 153000
M. Zavalishin
Ivanovo State University of Chemistry and Technology
Email: oxt705@isuct.ru
Ресей, Sheremetevskii pr. 7, Ivanovo, 153000
V. Aleksandriyskii
Ivanovo State University of Chemistry and Technology
Email: oxt705@isuct.ru
Ресей, Sheremetevskii pr. 7, Ivanovo, 153000
V. Sharnin
Ivanovo State University of Chemistry and Technology
Email: oxt705@isuct.ru
Ресей, Sheremetevskii pr. 7, Ivanovo, 153000