Ferric Chloride-catalyzed Synthesis of 2-Oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate Derivatives and Their Biological Evaluation
- Авторы: Sakram B.1, Madhu P.1, Sonyanaik B.1, Rambabu S.1, Ravi D.1, Kurumanna A.1
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Учреждения:
- Department of Chemistry
- Выпуск: Том 88, № 6 (2018)
- Страницы: 1224-1227
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222265
- DOI: https://doi.org/10.1134/S1070363218060294
- ID: 222265
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Аннотация
A new methodology has been developed for the synthesis of novel 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylates from 2-aminonicotinaldehyde, Meldrum’s acid, and the corresponding alcohols in the presence of anhydrous iron(III) chloride as a cheap and readily available catalyst. The structure of the synthesized compounds was established by IR, 1H NMR, and mass spectral data and elemental analyses. All the synthesized compounds were evaluated for their in vitro antibacterial and antifungal activity, and the activity of some derivatives was comparable with the activity of Ciprofloxacin and Nystatin used as reference drugs.
Об авторах
B. Sakram
Department of Chemistry
Автор, ответственный за переписку.
Email: bschemou@gmail.com
Индия, Hyderabad, 500007
P. Madhu
Department of Chemistry
Email: bschemou@gmail.com
Индия, Hyderabad, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
Индия, Hyderabad, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
Индия, Hyderabad, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
Индия, Hyderabad, 500007
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
Индия, Hyderabad, 500007