Ferric Chloride-catalyzed Synthesis of 2-Oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate Derivatives and Their Biological Evaluation
- 作者: Sakram B.1, Madhu P.1, Sonyanaik B.1, Rambabu S.1, Ravi D.1, Kurumanna A.1
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隶属关系:
- Department of Chemistry
- 期: 卷 88, 编号 6 (2018)
- 页面: 1224-1227
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222265
- DOI: https://doi.org/10.1134/S1070363218060294
- ID: 222265
如何引用文章
详细
A new methodology has been developed for the synthesis of novel 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylates from 2-aminonicotinaldehyde, Meldrum’s acid, and the corresponding alcohols in the presence of anhydrous iron(III) chloride as a cheap and readily available catalyst. The structure of the synthesized compounds was established by IR, 1H NMR, and mass spectral data and elemental analyses. All the synthesized compounds were evaluated for their in vitro antibacterial and antifungal activity, and the activity of some derivatives was comparable with the activity of Ciprofloxacin and Nystatin used as reference drugs.
作者简介
B. Sakram
Department of Chemistry
编辑信件的主要联系方式.
Email: bschemou@gmail.com
印度, Hyderabad, 500007
P. Madhu
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007