Synthesis and Biological Activity of Compounds Obtained by Reacting Methyl Aroylpyruvates with Sulfadimidine
- Авторы: Gein V.1, Bobrovskaya O.1, Dmitriev M.2, Makhmudov R.2, Belonogova V.1
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Учреждения:
- Perm State Pharmaceutical Academy
- Perm State National Research University
- Выпуск: Том 88, № 6 (2018)
- Страницы: 1095-1102
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222234
- DOI: https://doi.org/10.1134/S1070363218060087
- ID: 222234
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Аннотация
The reaction of methyl aroylpyruvates and 2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine in glacial acetic acid in the presence of anhydrous sodium acetate afforded (2Z)-4-aryl-2-hydroxy-N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-4-oxobut-2-enamides. Reaction of the above reagents in a mixture of acetic acid and ethanol (1: 1) in the absence of anhydrous sodium acetate gave methyl (2Z)-4-aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylamino}-4-oxobut-2-enoates. Analgesic and anti-inflammatory activities of the synthesized compounds was studied.
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Об авторах
V. Gein
Perm State Pharmaceutical Academy
Автор, ответственный за переписку.
Email: geinvl48@mail.ru
Россия, ul. Polevaya 2, Perm, 614990
O. Bobrovskaya
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Россия, ul. Polevaya 2, Perm, 614990
M. Dmitriev
Perm State National Research University
Email: geinvl48@mail.ru
Россия, Perm
R. Makhmudov
Perm State National Research University
Email: geinvl48@mail.ru
Россия, Perm
V. Belonogova
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Россия, ul. Polevaya 2, Perm, 614990