Synthesis and Biological Activity of Compounds Obtained by Reacting Methyl Aroylpyruvates with Sulfadimidine
- Authors: Gein V.L.1, Bobrovskaya O.V.1, Dmitriev M.V.2, Makhmudov R.R.2, Belonogova V.D.1
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Affiliations:
- Perm State Pharmaceutical Academy
- Perm State National Research University
- Issue: Vol 88, No 6 (2018)
- Pages: 1095-1102
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222234
- DOI: https://doi.org/10.1134/S1070363218060087
- ID: 222234
Cite item
Abstract
The reaction of methyl aroylpyruvates and 2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine in glacial acetic acid in the presence of anhydrous sodium acetate afforded (2Z)-4-aryl-2-hydroxy-N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-4-oxobut-2-enamides. Reaction of the above reagents in a mixture of acetic acid and ethanol (1: 1) in the absence of anhydrous sodium acetate gave methyl (2Z)-4-aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylamino}-4-oxobut-2-enoates. Analgesic and anti-inflammatory activities of the synthesized compounds was studied.
Keywords
About the authors
V. L. Gein
Perm State Pharmaceutical Academy
Author for correspondence.
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
O. V. Bobrovskaya
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
M. V. Dmitriev
Perm State National Research University
Email: geinvl48@mail.ru
Russian Federation, Perm
R. R. Makhmudov
Perm State National Research University
Email: geinvl48@mail.ru
Russian Federation, Perm
V. D. Belonogova
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990