Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives
- Autores: Yakantham T.1, Sreenivasulu R.1, Alluraiah G.1, Tej M.2, Ramesh Raju R.1
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Afiliações:
- Department of Chemistry
- Department of Pharmacy
- Edição: Volume 89, Nº 12 (2019)
- Páginas: 2522-2527
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223234
- DOI: https://doi.org/10.1134/S1070363219120314
- ID: 223234
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Resumo
A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by 1H and 13C NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.
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Sobre autores
T. Yakantham
Department of Chemistry
Email: rrraju1@gmail.com
Índia, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry
Email: rrraju1@gmail.com
Índia, Kakinada, Andhra Pradesh, 533003
G. Alluraiah
Department of Chemistry
Email: rrraju1@gmail.com
Índia, Giddalur, Andhra Pradesh, 523357
M. Tej
Department of Pharmacy
Email: rrraju1@gmail.com
Índia, Porur, Chennai, Tamil Nadu, 600116
R. Ramesh Raju
Department of Chemistry
Autor responsável pela correspondência
Email: rrraju1@gmail.com
Índia, Nagarjuna Nagar, Andhra Pradesh, 522510
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