Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives
- Authors: Yakantham T.1, Sreenivasulu R.1, Alluraiah G.1, Tej M.B.2, Ramesh Raju R.1
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Affiliations:
- Department of Chemistry
- Department of Pharmacy
- Issue: Vol 89, No 12 (2019)
- Pages: 2522-2527
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223234
- DOI: https://doi.org/10.1134/S1070363219120314
- ID: 223234
Cite item
Abstract
A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by 1H and 13C NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.
Keywords
About the authors
T. Yakantham
Department of Chemistry
Email: rrraju1@gmail.com
India, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry
Email: rrraju1@gmail.com
India, Kakinada, Andhra Pradesh, 533003
G. Alluraiah
Department of Chemistry
Email: rrraju1@gmail.com
India, Giddalur, Andhra Pradesh, 523357
M. B. Tej
Department of Pharmacy
Email: rrraju1@gmail.com
India, Porur, Chennai, Tamil Nadu, 600116
R. Ramesh Raju
Department of Chemistry
Author for correspondence.
Email: rrraju1@gmail.com
India, Nagarjuna Nagar, Andhra Pradesh, 522510