Enviar artigo por via de e-mail Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole-Isoxazole Linked Quinazoline Derivatives as Anticancer Agents
- Autores: Srinivas M.1, Satyaveni S.1, Ram B.2
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Afiliações:
- Department of Chemistry
- Green Evolution Laboratories
- Edição: Volume 89, Nº 12 (2019)
- Páginas: 2492-2497
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223224
- DOI: https://doi.org/10.1134/S1070363219120260
- ID: 223224
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Resumo
A series of novel 1,2,4-oxadiazole-isoxazole linked quinazoline compounds is designed, synthesized and screened for anticancer activity on four human cancer cell lines including MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay with etoposide used as a positive reference. All compounds demonstrate good to moderate anticancer activity and two compounds are found to be the most potent.
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Sobre autores
M. Srinivas
Department of Chemistry
Email: msrinivaschem1@gmail.com
Índia, Kakinada, 533003
S. Satyaveni
Department of Chemistry
Autor responsável pela correspondência
Email: msrinivaschem1@gmail.com
Índia, Kakinada, 533003
B. Ram
Green Evolution Laboratories
Email: msrinivaschem1@gmail.com
Índia, Wangapally Village, Nalgonda, AP, 508286
