Отправить статью по E-mail Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole-Isoxazole Linked Quinazoline Derivatives as Anticancer Agents
- Авторы: Srinivas M.1, Satyaveni S.1, Ram B.2
-
Учреждения:
- Department of Chemistry
- Green Evolution Laboratories
- Выпуск: Том 89, № 12 (2019)
- Страницы: 2492-2497
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223224
- DOI: https://doi.org/10.1134/S1070363219120260
- ID: 223224
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
A series of novel 1,2,4-oxadiazole-isoxazole linked quinazoline compounds is designed, synthesized and screened for anticancer activity on four human cancer cell lines including MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay with etoposide used as a positive reference. All compounds demonstrate good to moderate anticancer activity and two compounds are found to be the most potent.
Ключевые слова
Об авторах
M. Srinivas
Department of Chemistry
Email: msrinivaschem1@gmail.com
Индия, Kakinada, 533003
S. Satyaveni
Department of Chemistry
Автор, ответственный за переписку.
Email: msrinivaschem1@gmail.com
Индия, Kakinada, 533003
B. Ram
Green Evolution Laboratories
Email: msrinivaschem1@gmail.com
Индия, Wangapally Village, Nalgonda, AP, 508286
