Enviar artigo por via de e-mail Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity
- Autores: Baulin V.1,2, Kalashnikova I.1, Vikharev Y.1, Vikhareva E.1, Baulin D.2, Tsivadze A.2
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Afiliações:
- Institute of Physiologically Active Compounds
- Frumkin Institute of Physical Chemistry and Electrochemistry
- Edição: Volume 88, Nº 9 (2018)
- Páginas: 1786-1791
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222399
- DOI: https://doi.org/10.1134/S1070363218090049
- ID: 222399
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Resumo
The synthetically convenient method of preparation of unexplored phosphoryl analogs of salicylic acid (2-hydroxyphenylphosphonic and 2-hydroxyphenylphosphinic acids) has been developed for the search of novel nonsteroidal anti-inflammatory drugs. It has been shown that 2-hydroxyphenylphosphinic acid is a lowtoxic compound (LD50 3500 mg/kg) exhibiting analgesic activity significantly higher than both 2-hydroxyphenylphosphonic acid and the reference compound (sodium metamizole).
Sobre autores
V. Baulin
Institute of Physiologically Active Compounds; Frumkin Institute of Physical Chemistry and Electrochemistry
Autor responsável pela correspondência
Email: mager1988@gmail.com
Rússia, Severnii pr. 1, Chernogolovka, 142432; Moscow
I. Kalashnikova
Institute of Physiologically Active Compounds
Email: mager1988@gmail.com
Rússia, Severnii pr. 1, Chernogolovka, 142432
Yu. Vikharev
Institute of Physiologically Active Compounds
Email: mager1988@gmail.com
Rússia, Severnii pr. 1, Chernogolovka, 142432
E. Vikhareva
Institute of Physiologically Active Compounds
Email: mager1988@gmail.com
Rússia, Severnii pr. 1, Chernogolovka, 142432
D. Baulin
Frumkin Institute of Physical Chemistry and Electrochemistry
Email: mager1988@gmail.com
Rússia, Moscow
A. Tsivadze
Frumkin Institute of Physical Chemistry and Electrochemistry
Email: mager1988@gmail.com
Rússia, Moscow
