Email this article Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity
- Authors: Baulin V.E.1,2, Kalashnikova I.P.1, Vikharev Y.B.1, Vikhareva E.A.1, Baulin D.V.2, Tsivadze A.Y.2
-
Affiliations:
- Institute of Physiologically Active Compounds
- Frumkin Institute of Physical Chemistry and Electrochemistry
- Issue: Vol 88, No 9 (2018)
- Pages: 1786-1791
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222399
- DOI: https://doi.org/10.1134/S1070363218090049
- ID: 222399
Cite item
Open Access
Access granted
Subscription Access
Abstract
The synthetically convenient method of preparation of unexplored phosphoryl analogs of salicylic acid (2-hydroxyphenylphosphonic and 2-hydroxyphenylphosphinic acids) has been developed for the search of novel nonsteroidal anti-inflammatory drugs. It has been shown that 2-hydroxyphenylphosphinic acid is a lowtoxic compound (LD50 3500 mg/kg) exhibiting analgesic activity significantly higher than both 2-hydroxyphenylphosphonic acid and the reference compound (sodium metamizole).
About the authors
V. E. Baulin
Institute of Physiologically Active Compounds; Frumkin Institute of Physical Chemistry and Electrochemistry
Author for correspondence.
Email: mager1988@gmail.com
Russian Federation, Severnii pr. 1, Chernogolovka, 142432; Moscow
I. P. Kalashnikova
Institute of Physiologically Active Compounds
Email: mager1988@gmail.com
Russian Federation, Severnii pr. 1, Chernogolovka, 142432
Yu. B. Vikharev
Institute of Physiologically Active Compounds
Email: mager1988@gmail.com
Russian Federation, Severnii pr. 1, Chernogolovka, 142432
E. A. Vikhareva
Institute of Physiologically Active Compounds
Email: mager1988@gmail.com
Russian Federation, Severnii pr. 1, Chernogolovka, 142432
D. V. Baulin
Frumkin Institute of Physical Chemistry and Electrochemistry
Email: mager1988@gmail.com
Russian Federation, Moscow
A. Yu. Tsivadze
Frumkin Institute of Physical Chemistry and Electrochemistry
Email: mager1988@gmail.com
Russian Federation, Moscow
