Enviar artigo por via de e-mail Synthesis of New 2-(Oxiran-2-yl)-1,3-oxazoles
- Autores: Shablykin O.1, Volosheniuk M.2, Brovarets V.1
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Afiliações:
- Institute of Bioorganic Chemistry and Petrochemistry
- Taras Shevchenko National University of Kyiv
- Edição: Volume 88, Nº 7 (2018)
- Páginas: 1542-1545
- Seção: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222342
- DOI: https://doi.org/10.1134/S1070363218070307
- ID: 222342
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Resumo
Reaction of 2-chloro-N-(2,2-dichloro-1-cyanovinyl)acetamide with dimethylamine gave 5-(dimethylamino)-2-[(dimethylamino)methyl]-1,3-oxazole-4-carbonitrile, where aliphatic dimethylamino group was regioselectively alkylated with iodomethane. The resulting trimethylammonium salt reacted diastereoselectively with aromatic aldehydes to form new substituted 2-(oxiran-2-yl)-1,3-oxazoles.
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Sobre autores
O. Shablykin
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ucrânia, ul. Murmanskaya 1, Kyiv, 02094
M. Volosheniuk
Taras Shevchenko National University of Kyiv
Email: brovarets@bpci.kiev.ua
Ucrânia, Kyiv
V. Brovarets
Institute of Bioorganic Chemistry and Petrochemistry
Autor responsável pela correspondência
Email: brovarets@bpci.kiev.ua
Ucrânia, ul. Murmanskaya 1, Kyiv, 02094
