Synthesis of New 2-(Oxiran-2-yl)-1,3-oxazoles

O. V. Shablykin; M. A. Volosheniuk; V. S. Brovarets

doi:10.1134/S1070363218070307

Synthesis of New 2-(Oxiran-2-yl)-1,3-oxazoles

Authors: Shablykin O.V.¹, Volosheniuk M.A.², Brovarets V.S.¹
Affiliations:
1. Institute of Bioorganic Chemistry and Petrochemistry
2. Taras Shevchenko National University of Kyiv
Issue: Vol 88, No 7 (2018)
Pages: 1542-1545
Section: Letters to the Editor
URL: https://journals.rcsi.science/1070-3632/article/view/222342
DOI: https://doi.org/10.1134/S1070363218070307
ID: 222342

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Abstract

Reaction of 2-chloro-N-(2,2-dichloro-1-cyanovinyl)acetamide with dimethylamine gave 5-(dimethylamino)-2-[(dimethylamino)methyl]-1,3-oxazole-4-carbonitrile, where aliphatic dimethylamino group was regioselectively alkylated with iodomethane. The resulting trimethylammonium salt reacted diastereoselectively with aromatic aldehydes to form new substituted 2-(oxiran-2-yl)-1,3-oxazoles.