Microwave Assisted Synthesis and Antimicrobial Activity of (E)-1-{2/3/4-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones

Resumo

A novel series of (E)-1-{2/3/4-[(1-aryl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones is synthesised from terminal alkynes with aromatic azides by the Click reaction in the presence of copper sulphate and sodium ascorbate in DMF: water under microwave irradiation. All the synthesised compounds are characterised by IR, ¹H and ¹³C NMR, and mass spectra, and tested in vitro for antimicrobial activity.