New DNA Methylation Inhibitors Based on 1,2,4-Triazole Thioether Derivatives
- Autores: Hovsepyan T.1, Dilanyan S.1, Minasyan N.2, Arsenyan F.1, Nersesyan L.1, Agaronyan A.1, Danielyan I.1
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Afiliações:
- Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Edição: Volume 88, Nº 7 (2018)
- Páginas: 1390-1396
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222307
- DOI: https://doi.org/10.1134/S1070363218070071
- ID: 222307
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Resumo
New 4-substituted 4H-1,2,4-triazole-3-thiol derivatives were synthesized by introducing benzylsulfanylethyl groups in the 5-position of the heterocycle. Alkylation of the thiol group provides additional pharmacophore thioether, carboxamide, carboxyl, and hydroxyethyl fragments. Regardless of the nature of the substituents in the position 5 aminomethylation and cyanoethylation proceed at the N2 atom. The synthesized compounds were studied for anti-tumor activity and the effect on the methylation level of tumor DNA.
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Sobre autores
T. Hovsepyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Autor responsável pela correspondência
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
S. Dilanyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
N. Minasyan
Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Armênia, Yerevan
F. Arsenyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
L. Nersesyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
A. Agaronyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
I. Danielyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
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