New DNA Methylation Inhibitors Based on 1,2,4-Triazole Thioether Derivatives
- Авторы: Hovsepyan T.1, Dilanyan S.1, Minasyan N.2, Arsenyan F.1, Nersesyan L.1, Agaronyan A.1, Danielyan I.1
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Учреждения:
- Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Выпуск: Том 88, № 7 (2018)
- Страницы: 1390-1396
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222307
- DOI: https://doi.org/10.1134/S1070363218070071
- ID: 222307
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Аннотация
New 4-substituted 4H-1,2,4-triazole-3-thiol derivatives were synthesized by introducing benzylsulfanylethyl groups in the 5-position of the heterocycle. Alkylation of the thiol group provides additional pharmacophore thioether, carboxamide, carboxyl, and hydroxyethyl fragments. Regardless of the nature of the substituents in the position 5 aminomethylation and cyanoethylation proceed at the N2 atom. The synthesized compounds were studied for anti-tumor activity and the effect on the methylation level of tumor DNA.
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Об авторах
T. Hovsepyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Автор, ответственный за переписку.
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
S. Dilanyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
N. Minasyan
Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Армения, Yerevan
F. Arsenyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
L. Nersesyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
A. Agaronyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
I. Danielyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
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