Synthesis and Characterization of Disulfide-Schiff Base Derivatives and in vitro Investigation of Their Antibacterial Activity Against Multidrug-Resistant Acinetobacter baumannii Isolates: A New Study

Resumo

In this study two different methods without a catalyst and with a CeO₂ nano catalyst were used for the synthesis of dimeric disulfide-Schiff bases. The dimeric disulfide-Schiff base derivatives were characterized by FT-IR, NMR, and MS spectra, and elemental analysis. The disulfide-Schiff bases and their derivatives 2–5c were screened for in vitro antibacterial activity against 40 multidrug-resistant strains of Acinetobacter baumannii, and their minimum inhibitory concentrations were determined. Most of products exhibited high antibacterial activity against Acinetobacter baumannii.