Isatin Derivatives Containing Sterically Hindered Phenolic Fragment and Water-Soluble Acyl Hydrazones on Their Basis: Synthesis and Antimicrobial Activity
- Autores: Bogdanov A.1, Zaripova I.2, Voloshina A.1, Strobykina A.1, Kulik N.1, Bukharov S.2, Mironov V.1
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Afiliações:
- A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
- Kazan National Research Technological University
- Edição: Volume 88, Nº 1 (2018)
- Páginas: 57-67
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221942
- DOI: https://doi.org/10.1134/S1070363218010097
- ID: 221942
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Resumo
Condensation reactions of isatin derivatives with 3,5-di(tert-butyl)-4-hydroxybenzyl acetate and the Girard’s reagent T has afforded a series of novel water-soluble isatin-3-acyl hydrazones containing a sterically hindered phenolic fragment in position 1 of the heterocycle; antimicrobial activity of the products has been estimated. It has been shown that the isatin derivatives with bromine or methoxy substituent in the benzo fragment as well as the acyl hydrazones containing 5-methyl or 5-ethyl group are the most active against Staphylococcus aureus and Bacillus cereus.
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Sobre autores
A. Bogdanov
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Autor responsável pela correspondência
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
I. Zaripova
Kazan National Research Technological University
Email: abogdanov@inbox.ru
Rússia, Kazan, Tatarstan
A. Voloshina
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
A. Strobykina
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
N. Kulik
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
S. Bukharov
Kazan National Research Technological University
Email: abogdanov@inbox.ru
Rússia, Kazan, Tatarstan
V. Mironov
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
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