Polysubstituted Ionol Derivatives as Inhibitors of Lipid Peroxidation
- Autores: Osipova V.1, Kolyada M.1, Kudryavtsev K.2, Berberova N.3, Pimenov Y.3, Milaeva E.2
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Afiliações:
- Southern Scientific Center
- Moscow State University
- Astrakhan State Technical University
- Edição: Volume 87, Nº 13 (2017)
- Páginas: 3144-3150
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221884
- DOI: https://doi.org/10.1134/S1070363217130060
- ID: 221884
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Resumo
Polysubstituted derivatives of sterically hindered phenol were found to reduce accumulation of hydroperoxides in the lipid extract from fish feed after 8-week incubation. Feeding of juvenile Russian sturgeon with fish food containing these compounds showed no negative effect on hydrobionts. Both in vivo and in vitro experiments revealed inhibition of hepatic lipid oxidation in juvenile Russian sturgeon in the presence of new bis-pyrrolidine derivatives of 2,6-di-tert-butylphenol. A reliable positive correlation was observed between the concentration of hydroperoxides in the lipid extract from fish feed and accumulation level of secondary enzymatic oxidation products of hepatic lipids in hydrobionts.
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Sobre autores
V. Osipova
Southern Scientific Center
Autor responsável pela correspondência
Email: osipova_vp@mail.ru
Rússia, pr. Chekhova 41, Rostov-on-Don, 344006
M. Kolyada
Southern Scientific Center
Email: osipova_vp@mail.ru
Rússia, pr. Chekhova 41, Rostov-on-Don, 344006
K. Kudryavtsev
Moscow State University
Email: osipova_vp@mail.ru
Rússia, Leninskie gory 1, Moscow, 119991
N. Berberova
Astrakhan State Technical University
Email: osipova_vp@mail.ru
Rússia, ul. Tatishcheva 16, Astrakhan, 414025
Yu. Pimenov
Astrakhan State Technical University
Email: osipova_vp@mail.ru
Rússia, ul. Tatishcheva 16, Astrakhan, 414025
E. Milaeva
Moscow State University
Email: osipova_vp@mail.ru
Rússia, Leninskie gory 1, Moscow, 119991