Polysubstituted Ionol Derivatives as Inhibitors of Lipid Peroxidation

Abstract

Polysubstituted derivatives of sterically hindered phenol were found to reduce accumulation of hydroperoxides in the lipid extract from fish feed after 8-week incubation. Feeding of juvenile Russian sturgeon with fish food containing these compounds showed no negative effect on hydrobionts. Both in vivo and in vitro experiments revealed inhibition of hepatic lipid oxidation in juvenile Russian sturgeon in the presence of new bis-pyrrolidine derivatives of 2,6-di-tert-butylphenol. A reliable positive correlation was observed between the concentration of hydroperoxides in the lipid extract from fish feed and accumulation level of secondary enzymatic oxidation products of hepatic lipids in hydrobionts.