Synthesis of N-methylpiperidin-4-one derivatives and evaluation of their anti-endometrial cancer activity
- Autores: Lai G.1, Huang Y.2, Zhang B.3
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Afiliações:
- Department of Human Anatomy
- Department of Chemistry
- Department of Rheumatology
- Edição: Volume 87, Nº 5 (2017)
- Páginas: 1053-1056
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/219930
- DOI: https://doi.org/10.1134/S1070363217050267
- ID: 219930
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Resumo
Four novel N-methylpiperidin-4-one derivatives were synthesized and characterized by IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The anticancer activity of these compounds was studied on five human endometrial cancer cell lines (RL-95-2, HEC-1A, HEC-1B, AN3CN and HECCL-1). Efficient antitumor effect was found for the 3,5-difluorophenyl- and 3-cyanophenyl-substituted derivatives.
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Sobre autores
Gui-Hua Lai
Department of Human Anatomy
Email: baiyu_zhang666@yeah.net
República Popular da China, Bengbu, Anhui
Yu-Lan Huang
Department of Chemistry
Email: baiyu_zhang666@yeah.net
República Popular da China, Bengbu, Anhui
Bai-Yu Zhang
Department of Rheumatology
Autor responsável pela correspondência
Email: baiyu_zhang666@yeah.net
República Popular da China, Guangzhou, Guangdong