Synthesis of N-methylpiperidin-4-one derivatives and evaluation of their anti-endometrial cancer activity

Abstract

Four novel N-methylpiperidin-4-one derivatives were synthesized and characterized by IR, ¹H NMR, HRMS, and single crystal X-ray crystallography. The anticancer activity of these compounds was studied on five human endometrial cancer cell lines (RL-95-2, HEC-1A, HEC-1B, AN3CN and HECCL-1). Efficient antitumor effect was found for the 3,5-difluorophenyl- and 3-cyanophenyl-substituted derivatives.