Homobimetallic organotin(IV) complexes with succinohydrazide Schiff base: Synthesis, spectroscopic characterization, and biological screening

Resumo

Six new bis-diorganotin(IV) complexes, [(Me₂Sn)₂L] (1), [(Et₂Sn)₂L] (2), [(n-Bu₂Sn)₂L] (3), [(Ph₂Sn)₂L] (4), [(n-Oct₂Sn)₂L] (5), and [(tert-C₄H₉)₂Sn)₂L] (6), where L = N^1',N^4'-bis(2-oxidobenzylidene)-succinohydrazide, were synthesized and characterized by elemental analysis, FT-IR, NMR (¹H, ¹³C, and ¹¹⁹Sn) and Mass spectra. Spectroscopic data authenticated the existence of two pentacoordinated tin centers in all complexes, formed via coordination of bis-ONO donor sites with dialkyltin(IV) moieties. Biological screening against selected pathogenic strains of bacteria and fungi revealed high activity of compound 3 against Bacillus subtilis and Aspergillus flavis, it also exhibited highest cytotoxicity against Artemia salina.