New derivatives of 1,3,4-thiadiazole based on hydrazide of 3-methoxyphenoxyacetic acid


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2-Substituted 1,3,4-thiadiazole-5-thiol has been synthesized basing on hydrazide of 3-methoxy-phenoxyacetic acid. Methods of SH-alkylation, aminomethylation, and cyanoethylation of the product have been elaborated. Reactions of the starting hydrazide leading to 4-amino-3,5-substituted 4Н-1,2,4-triazoles and acyl hydrazides of dicarboxylic acids containing pharmacophore groups in the molecule have been studied.

Sobre autores

T. Hovsepyan

A.L. Mnjoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry

Autor responsável pela correspondência
Email: tag.hovsepyan@mail.ru
Armênia, Azatutyan ave. 26, Yerevan, 0014

M. Hakobyan

A.L. Mnjoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry

Email: tag.hovsepyan@mail.ru
Armênia, Azatutyan ave. 26, Yerevan, 0014

N. Minasyan

Center for Investigation of Molecules Structures, Scientific-Technological Center of Organic and Pharmaceutical Chemistry

Email: tag.hovsepyan@mail.ru
Armênia, Yerevan

R. Melik-Ohanjanyan

A.L. Mnjoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry

Email: tag.hovsepyan@mail.ru
Armênia, Azatutyan ave. 26, Yerevan, 0014

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