Email this article New derivatives of 1,3,4-thiadiazole based on hydrazide of 3-methoxyphenoxyacetic acid
- Authors: Hovsepyan T.R.1, Hakobyan M.R.1, Minasyan N.S.2, Melik-Ohanjanyan R.G.1
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Affiliations:
- A.L. Mnjoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
- Center for Investigation of Molecules Structures, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
- Issue: Vol 86, No 8 (2016)
- Pages: 1845-1849
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215924
- DOI: https://doi.org/10.1134/S1070363216080119
- ID: 215924
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Abstract
2-Substituted 1,3,4-thiadiazole-5-thiol has been synthesized basing on hydrazide of 3-methoxy-phenoxyacetic acid. Methods of SH-alkylation, aminomethylation, and cyanoethylation of the product have been elaborated. Reactions of the starting hydrazide leading to 4-amino-3,5-substituted 4Н-1,2,4-triazoles and acyl hydrazides of dicarboxylic acids containing pharmacophore groups in the molecule have been studied.
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About the authors
T. R. Hovsepyan
A.L. Mnjoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Author for correspondence.
Email: tag.hovsepyan@mail.ru
Armenia, Azatutyan ave. 26, Yerevan, 0014
M. R. Hakobyan
A.L. Mnjoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armenia, Azatutyan ave. 26, Yerevan, 0014
N. S. Minasyan
Center for Investigation of Molecules Structures, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armenia, Yerevan
R. G. Melik-Ohanjanyan
A.L. Mnjoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armenia, Azatutyan ave. 26, Yerevan, 0014
