Synthesis, spectroscopic, and antimicrobial study of Ca(II), Fe(III), Pd(II), and Au(III) complexes of amoxicillin antibiotic drug
- Autores: Al-Khodir F.1,2, Refat M.3,4
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Afiliações:
- Department of Chemistry, College of Science
- Deanship of Scientific Research
- Department of Chemistry
- Department of Chemistry, Faculty of Sciences
- Edição: Volume 86, Nº 3 (2016)
- Páginas: 708-717
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214454
- DOI: https://doi.org/10.1134/S1070363216030324
- ID: 214454
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Resumo
Synthesis, spectroscopic characterization, theoretical and antimicrobial studies of Ca(II), Fe(III), Pd(II), and Au(III) complexes of amoxicillin (amox) antibiotic drug are presented in the current paper. Structure of 1: 1 (metal: amox) complexes were elucidated on the basis of elemental analyses, and IR, Raman, 1H NMR, and electronic spectral data. According to molar conductance measurements the complexes had electrolyte nature. Amoxicillin reacted with metal ions as a tridentate ligand coordinated with metal ions via–NH2,–NH, and β-lactam carbonyl groups. The complexes were formulated as [Ca(amox-Na)(H2O)]·Cl2·4H2O (1), [Fe(amox-Na)(H2O)3]·Cl3·3H2O (2), [Pd(amox-Na)(H2O)]·Cl2 (3), and [Au(amox-Na)(H2O)]·Cl3 (4). Kinetic thermodynamic parameters (E*, ΔS*, ΔH*, and ΔG*) were calculated based on the Coats–Redfern and Horowitz–Metzger methods using thermo gravimetric curves of TG and DTG. Nanosize particles of amoxicillin complexes have been studied by XRD, SEM, and TEM methods. Theoretical studies of the synthesized complexes have been performed.
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Sobre autores
F. Al-Khodir
Department of Chemistry, College of Science; Deanship of Scientific Research
Email: msrefat@yahoo.com
Arábia Saudita, Riyadh; Riyadh
M. Refat
Department of Chemistry; Department of Chemistry, Faculty of Sciences
Autor responsável pela correspondência
Email: msrefat@yahoo.com
Egito, Cairo; Taif, P.O. Box 88821974
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