Synthesis, spectroscopic, and antimicrobial study of Ca(II), Fe(III), Pd(II), and Au(III) complexes of amoxicillin antibiotic drug
- Authors: Al-Khodir F.A.1,2, Refat M.S.3,4
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Affiliations:
- Department of Chemistry, College of Science
- Deanship of Scientific Research
- Department of Chemistry
- Department of Chemistry, Faculty of Sciences
- Issue: Vol 86, No 3 (2016)
- Pages: 708-717
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214454
- DOI: https://doi.org/10.1134/S1070363216030324
- ID: 214454
Cite item
Abstract
Synthesis, spectroscopic characterization, theoretical and antimicrobial studies of Ca(II), Fe(III), Pd(II), and Au(III) complexes of amoxicillin (amox) antibiotic drug are presented in the current paper. Structure of 1: 1 (metal: amox) complexes were elucidated on the basis of elemental analyses, and IR, Raman, 1H NMR, and electronic spectral data. According to molar conductance measurements the complexes had electrolyte nature. Amoxicillin reacted with metal ions as a tridentate ligand coordinated with metal ions via–NH2,–NH, and β-lactam carbonyl groups. The complexes were formulated as [Ca(amox-Na)(H2O)]·Cl2·4H2O (1), [Fe(amox-Na)(H2O)3]·Cl3·3H2O (2), [Pd(amox-Na)(H2O)]·Cl2 (3), and [Au(amox-Na)(H2O)]·Cl3 (4). Kinetic thermodynamic parameters (E*, ΔS*, ΔH*, and ΔG*) were calculated based on the Coats–Redfern and Horowitz–Metzger methods using thermo gravimetric curves of TG and DTG. Nanosize particles of amoxicillin complexes have been studied by XRD, SEM, and TEM methods. Theoretical studies of the synthesized complexes have been performed.
Keywords
About the authors
F. A. I. Al-Khodir
Department of Chemistry, College of Science; Deanship of Scientific Research
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh; Riyadh
M. S. Refat
Department of Chemistry; Department of Chemistry, Faculty of Sciences
Author for correspondence.
Email: msrefat@yahoo.com
Egypt, Cairo; Taif, P.O. Box 88821974
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