Synthesis and Antibacterial Activity of Novel 3-N-Substituted 1,8-Naphthyridin-2(1H)-ones
- Авторлар: Sakram B.1, Kurumanna A.1, Ashok K.1, Rambabu S.1, Ravi D.1, Sathish Kumar B.1
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Мекемелер:
- Department of Chemistry
- Шығарылым: Том 89, № 12 (2019)
- Беттер: 2534-2543
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223242
- DOI: https://doi.org/10.1134/S1070363219120338
- ID: 223242
Дәйексөз келтіру
Аннотация
Synthesis of novel N-protected and unprotected 3-N-substituted 1,8-naphthyridin-2(1H)-ones with potential inhibiting activity of penicillin-binding protein 6 (PBP6) has been developed. The synthesis is designed around a Buchwald–Hartwig crosscoupling of various 3-bromo-6-substituted-1,8-naphthyridin-2(1H)-ones with two different functionalized anilines. According to the preliminary antibacterial evaluation, the products 9b–9d and 10b–10d have demonstrated high inhibiting activity against spore germination of Staphylococcus aureus (gram positive) and Escherichia coli (gram negative). The molecular docking procedure has denoted the probable interactions of the synthesized compounds 9b–9d and 10b–10d with the target protein.
Авторлар туралы
B. Sakram
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
B. Sathish Kumar
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007