Synthesis and Antibacterial Activity of Novel 3-N-Substituted 1,8-Naphthyridin-2(1H)-ones
- 作者: Sakram B.1, Kurumanna A.1, Ashok K.1, Rambabu S.1, Ravi D.1, Sathish Kumar B.1
-
隶属关系:
- Department of Chemistry
- 期: 卷 89, 编号 12 (2019)
- 页面: 2534-2543
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223242
- DOI: https://doi.org/10.1134/S1070363219120338
- ID: 223242
如何引用文章
详细
Synthesis of novel N-protected and unprotected 3-N-substituted 1,8-naphthyridin-2(1H)-ones with potential inhibiting activity of penicillin-binding protein 6 (PBP6) has been developed. The synthesis is designed around a Buchwald–Hartwig crosscoupling of various 3-bromo-6-substituted-1,8-naphthyridin-2(1H)-ones with two different functionalized anilines. According to the preliminary antibacterial evaluation, the products 9b–9d and 10b–10d have demonstrated high inhibiting activity against spore germination of Staphylococcus aureus (gram positive) and Escherichia coli (gram negative). The molecular docking procedure has denoted the probable interactions of the synthesized compounds 9b–9d and 10b–10d with the target protein.
作者简介
B. Sakram
Department of Chemistry
编辑信件的主要联系方式.
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
B. Sathish Kumar
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
![](/img/style/loading.gif)