Synthesis and Cyclizations of N-(Thieno[2,3-b]pyridin-3-yl)cyanoacetamides
- Авторлар: Chigorina E.1, Bespalov A.2, Dotsenko V.2,3
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Мекемелер:
- Institute of Chemical Reagents and High Purity Chemical Substances of National Research Centre “Kurchatov Institute,”
- Kuban State University
- North-Caucasian Federal University
- Шығарылым: Том 89, № 10 (2019)
- Беттер: 2018-2026
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223109
- DOI: https://doi.org/10.1134/S1070363219100062
- ID: 223109
Дәйексөз келтіру
Аннотация
3-Aminothieno[2,3-b]pyridine-2-carboxylic acid esters readily reacted with 3,5-dimethyl-1-(cyanoacetyl)-1H-pyrazole to give previously unknown N-(thieno[2,3-b]pyridin-3-yl)cyanoacetamides. Reactions of the latter with 2-(arylmethylidene)malononitriles were nonselective, and mixtures of different heterocyclization products were generally formed. The cyclization of ethyl 4,6-dimethyl-3-[(cyanoacetyl)amino]thieno[2,3-b]-pyridine-2-carboxylate afforded 2,4-dihydroxy-7,9-dimethylthieno[2,3-b : 4,5-b′]dipyridine-3-carbonitrile whose tautomeric equilibrium was studied by DFT quantum chemical calculations. In silico analysis of biological activity of the synthesized compounds was performed.
Авторлар туралы
E. Chigorina
Institute of Chemical Reagents and High Purity Chemical Substances of National Research Centre “Kurchatov Institute,”
Email: victor_dotsenko_@mail.ru
Ресей, Moscow
A. Bespalov
Kuban State University
Email: victor_dotsenko_@mail.ru
Ресей, Krasnodar
V. Dotsenko
Kuban State University; North-Caucasian Federal University
Хат алмасуға жауапты Автор.
Email: victor_dotsenko_@mail.ru
Ресей, Krasnodar; Stavropol