New Chalcone Derivatives with Schiff Base-Thiophene: Synthesis, Biological Activity, and Molecular Docking Studies
- Авторлар: Ünver Y.1, Tuluk M.1, Kahriman N.1, Emirik M.2, Bektaş E.3, Direkel Ş.4
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Мекемелер:
- Department of Chemistry, Faculty of Science
- Department of Chemistry, Faculty of Art and Sciences
- Giresun University, Espiye Vocational School
- Department of Medical Microbiology, Faculty of Medicine
- Шығарылым: Том 89, № 4 (2019)
- Беттер: 794-799
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222873
- DOI: https://doi.org/10.1134/S107036321904025X
- ID: 222873
Дәйексөз келтіру
Аннотация
New thiophene chalcones 3, 6 and thiophene Schiff base-chalcone derivatives 4a–4d, 7a–7d are synthesized. Structures of the compounds are confirmed by 1H and 13C NMR, and IR spectra. According to antimicrobial and antileishmanial tests, the compounds 4c–7c demonstrate efficient antileishmanial and antimicrobial activities. Molecular docking studies based on Maestro Molecular Modeling indicate 4c and 7c to be the most potent compounds that are characterized by the least docking score,–10.674 and–10.989 kcal/mol, respectively.
Негізгі сөздер
Авторлар туралы
Y. Ünver
Department of Chemistry, Faculty of Science
Хат алмасуға жауапты Автор.
Email: unver.yasemincan@hotmail.com
Түркия, Trabzon, 61080
M. Tuluk
Department of Chemistry, Faculty of Science
Email: unver.yasemincan@hotmail.com
Түркия, Trabzon, 61080
N. Kahriman
Department of Chemistry, Faculty of Science
Email: unver.yasemincan@hotmail.com
Түркия, Trabzon, 61080
M. Emirik
Department of Chemistry, Faculty of Art and Sciences
Email: unver.yasemincan@hotmail.com
Түркия, Rize, 53100
E. Bektaş
Giresun University, Espiye Vocational School
Email: unver.yasemincan@hotmail.com
Түркия, Espiye, Giresun, 28600
Ş. Direkel
Department of Medical Microbiology, Faculty of Medicine
Email: unver.yasemincan@hotmail.com
Түркия, Giresun, 28100