New Chalcone Derivatives with Schiff Base-Thiophene: Synthesis, Biological Activity, and Molecular Docking Studies
- Authors: Ünver Y.1, Tuluk M.1, Kahriman N.1, Emirik M.2, Bektaş E.3, Direkel Ş.4
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Affiliations:
- Department of Chemistry, Faculty of Science
- Department of Chemistry, Faculty of Art and Sciences
- Giresun University, Espiye Vocational School
- Department of Medical Microbiology, Faculty of Medicine
- Issue: Vol 89, No 4 (2019)
- Pages: 794-799
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222873
- DOI: https://doi.org/10.1134/S107036321904025X
- ID: 222873
Cite item
Abstract
New thiophene chalcones 3, 6 and thiophene Schiff base-chalcone derivatives 4a–4d, 7a–7d are synthesized. Structures of the compounds are confirmed by 1H and 13C NMR, and IR spectra. According to antimicrobial and antileishmanial tests, the compounds 4c–7c demonstrate efficient antileishmanial and antimicrobial activities. Molecular docking studies based on Maestro Molecular Modeling indicate 4c and 7c to be the most potent compounds that are characterized by the least docking score,–10.674 and–10.989 kcal/mol, respectively.
About the authors
Y. Ünver
Department of Chemistry, Faculty of Science
Author for correspondence.
Email: unver.yasemincan@hotmail.com
Turkey, Trabzon, 61080
M. Tuluk
Department of Chemistry, Faculty of Science
Email: unver.yasemincan@hotmail.com
Turkey, Trabzon, 61080
N. Kahriman
Department of Chemistry, Faculty of Science
Email: unver.yasemincan@hotmail.com
Turkey, Trabzon, 61080
M. Emirik
Department of Chemistry, Faculty of Art and Sciences
Email: unver.yasemincan@hotmail.com
Turkey, Rize, 53100
E. Bektaş
Giresun University, Espiye Vocational School
Email: unver.yasemincan@hotmail.com
Turkey, Espiye, Giresun, 28600
Ş. Direkel
Department of Medical Microbiology, Faculty of Medicine
Email: unver.yasemincan@hotmail.com
Turkey, Giresun, 28100