A novel and efficient synthesis of 3-iodo substituted 1,8-naphthyridines by electrophilic cyclization of 2-amino nicotinaldehyde and their antimicrobial activity
- Авторлар: Sakram B.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Ravi D.1
-
Мекемелер:
- Department of Chemistry
- Шығарылым: Том 87, № 8 (2017)
- Беттер: 1794-1799
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221072
- DOI: https://doi.org/10.1134/S1070363217080266
- ID: 221072
Дәйексөз келтіру
Аннотация
Synthesis of substituted 1,8-naphthyridines based on 2-aminonicotinaldehyde under mild conditions is studied. Out of three electrophilic iodine sources (I2, NIS, and ICl) studied, I2 was determined to act most efficiently in the process. High overall yields were achieved for aliphatic substitution at the reaction center. All compounds were evaluated for antibacterial activity (Staphylococus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia) and anti-fungi activity (Aspergillus flavus and Fusarium oxysporum).
Негізгі сөздер
Авторлар туралы
B. Sakram
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: bschemou@gmail.com
Үндістан, Hyderabad, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Hyderabad, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Hyderabad, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Hyderabad, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Hyderabad, 500007