Synthesis and Antibacterial Activity of Benzenesulfonylhydrazone Derivatives of Methyl Dehydroabietate
- Authors: Zhou Z.1, Wang X.1, Zhou T.2
-
Affiliations:
- School of Life and Health Science
- Clinical Laboratory
- Issue: Vol 89, No 4 (2019)
- Pages: 819-823
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222879
- DOI: https://doi.org/10.1134/S1070363219040297
- ID: 222879
Cite item
Abstract
Six benzenesulfonylhydrazone derivatives of methyl dehydroabietate are synthesized via esterification, benzylic oxidation, condensation with hydrazine hydrate, and following nucleophilic substitution reaction with a variety of substituted benzenesulfonyl chloride. The structures of the synthesized compounds are characterized by 1H NMR and MS spectra. Antibacterial activity of the target compounds is evaluated by disk diffusion method against E. coli, S. aureus, and B. subtilis. The results demonstrate that benzenesulfonylhydrazone derivatives of methyl dehydroabietate exhibit inhibitory activity. Among the six compounds, p-fluorobenzenesulfonylhydrazone of methyl dehydroabietate exhibits the highest antibacterial activity with the zone of inhibition of 17.3 mm against B. subtilis and 16.5 mm against S. aureus.
About the authors
Zhi Zhou
School of Life and Health Science
Author for correspondence.
Email: zhou86zhi@163.com
China, Kaiyuan Road 3, Kaili, Guizhou, 556011
Xiang Wang
School of Life and Health Science
Email: zhou86zhi@163.com
China, Kaiyuan Road 3, Kaili, Guizhou, 556011
Tingting Zhou
Clinical Laboratory
Email: zhou86zhi@163.com
China, Renmin Road 343, Yuping, Guizhou, 554000