Synthesis and Antibacterial Activity of Benzenesulfonylhydrazone Derivatives of Methyl Dehydroabietate

Abstract

Six benzenesulfonylhydrazone derivatives of methyl dehydroabietate are synthesized via esterification, benzylic oxidation, condensation with hydrazine hydrate, and following nucleophilic substitution reaction with a variety of substituted benzenesulfonyl chloride. The structures of the synthesized compounds are characterized by ¹H NMR and MS spectra. Antibacterial activity of the target compounds is evaluated by disk diffusion method against E. coli, S. aureus, and B. subtilis. The results demonstrate that benzenesulfonylhydrazone derivatives of methyl dehydroabietate exhibit inhibitory activity. Among the six compounds, p-fluorobenzenesulfonylhydrazone of methyl dehydroabietate exhibits the highest antibacterial activity with the zone of inhibition of 17.3 mm against B. subtilis and 16.5 mm against S. aureus.