Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide
- Authors: Baklykov A.V.1,2, Rusinov G.L.1,2, Rusinov V.L.1,2, Charushin V.N.1,2, Kopchuk D.S.1,2, Zyryanov G.V.1,2, Artem’ev G.A.1
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Affiliations:
- Postovskii Institute of Organic Synthesis, Ural Branch
- Yeltsin Ural Federal University
- Issue: Vol 89, No 1 (2019)
- Pages: 151-152
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222726
- DOI: https://doi.org/10.1134/S1070363219010274
- ID: 222726
Cite item
Abstract
5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3H-1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl2 in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%.
About the authors
A. V. Baklykov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
G. L. Rusinov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
V. L. Rusinov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
V. N. Charushin
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
D. S. Kopchuk
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
G. V. Zyryanov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Author for correspondence.
Email: gvzyryanov@gmail.com
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
G. A. Artem’ev
Postovskii Institute of Organic Synthesis, Ural Branch
Email: gvzyryanov@gmail.com
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990