Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide
- Autores: Baklykov A.1,2, Rusinov G.1,2, Rusinov V.1,2, Charushin V.1,2, Kopchuk D.1,2, Zyryanov G.1,2, Artem’ev G.1
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Afiliações:
- Postovskii Institute of Organic Synthesis, Ural Branch
- Yeltsin Ural Federal University
- Edição: Volume 89, Nº 1 (2019)
- Páginas: 151-152
- Seção: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222726
- DOI: https://doi.org/10.1134/S1070363219010274
- ID: 222726
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Resumo
5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3H-1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl2 in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%.
Sobre autores
A. Baklykov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Rússia, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
G. Rusinov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Rússia, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
V. Rusinov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Rússia, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
V. Charushin
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Rússia, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
D. Kopchuk
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: gvzyryanov@gmail.com
Rússia, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
G. Zyryanov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Autor responsável pela correspondência
Email: gvzyryanov@gmail.com
Rússia, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990; ul. Mira 19, Yekaterinburg, 620002
G. Artem’ev
Postovskii Institute of Organic Synthesis, Ural Branch
Email: gvzyryanov@gmail.com
Rússia, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990