2,5-Diamino-5,5-diphosphonovaleric Acid as a Ligand for an Osteotropic 188Re Radiopharmaceutical
- Authors: Tsebrikova G.S.1, Ragulin V.V.2, Baulin V.E.1,2, German K.E.1, Malysheva A.O.3, Klement’eva O.E.3, Kodina G.E.3, Larenkov A.A.3, Lyamtseva E.A.3, Taratonenkova N.A.3, Zhukova M.V.1, Tsivadze A.Y.1
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Affiliations:
- A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
- Institute of Physiologically Active Compounds
- Burnazyan Federal Medical Biophysical Center
- Issue: Vol 88, No 9 (2018)
- Pages: 1780-1785
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222398
- DOI: https://doi.org/10.1134/S1070363218090037
- ID: 222398
Cite item
Abstract
A modified method for the preparation of 2,5-diamino-5,5-diphosphonovaleric acid (DADP5) has been developed in the search for new synthetically available organic ligands to produce 188Re radiopharmaceuticals with an increased accumulation in the bone tissue. Interaction of the obtained acid with 188Re was studied by radio-TLC. An optimal system for separating unbound 188Re and labeled complex in a yield of at least 95% was found. The biological distribution of 188Re-DADP5 was studied based on direct radiometric data. The osteotropicity of 188Re-DADP5 and its increased accumulation in bone fracture sites, which represent oncological pathology models, was detected at a level comparable to known radiopharmaceuticals.
About the authors
G. S. Tsebrikova
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
Author for correspondence.
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071
V. V. Ragulin
Institute of Physiologically Active Compounds
Email: tsebrikova@yandex.ru
Russian Federation, Chernogolovka, Moscow oblast
V. E. Baulin
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry; Institute of Physiologically Active Compounds
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071; Chernogolovka, Moscow oblast
K. E. German
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071
A. O. Malysheva
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Russian Federation, Moscow
O. E. Klement’eva
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Russian Federation, Moscow
G. E. Kodina
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Russian Federation, Moscow
A. A. Larenkov
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Russian Federation, Moscow
E. A. Lyamtseva
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Russian Federation, Moscow
N. A. Taratonenkova
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Russian Federation, Moscow
M. V. Zhukova
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071
A. Yu. Tsivadze
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071