2,5-Diamino-5,5-diphosphonovaleric Acid as a Ligand for an Osteotropic 188Re Radiopharmaceutical
- Авторы: Tsebrikova G.1, Ragulin V.2, Baulin V.1,2, German K.1, Malysheva A.3, Klement’eva O.3, Kodina G.3, Larenkov A.3, Lyamtseva E.3, Taratonenkova N.3, Zhukova M.1, Tsivadze A.1
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Учреждения:
- A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
- Institute of Physiologically Active Compounds
- Burnazyan Federal Medical Biophysical Center
- Выпуск: Том 88, № 9 (2018)
- Страницы: 1780-1785
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222398
- DOI: https://doi.org/10.1134/S1070363218090037
- ID: 222398
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Аннотация
A modified method for the preparation of 2,5-diamino-5,5-diphosphonovaleric acid (DADP5) has been developed in the search for new synthetically available organic ligands to produce 188Re radiopharmaceuticals with an increased accumulation in the bone tissue. Interaction of the obtained acid with 188Re was studied by radio-TLC. An optimal system for separating unbound 188Re and labeled complex in a yield of at least 95% was found. The biological distribution of 188Re-DADP5 was studied based on direct radiometric data. The osteotropicity of 188Re-DADP5 and its increased accumulation in bone fracture sites, which represent oncological pathology models, was detected at a level comparable to known radiopharmaceuticals.
Об авторах
G. Tsebrikova
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
Автор, ответственный за переписку.
Email: tsebrikova@yandex.ru
Россия, Leninskii pr. 31/4, Moscow, 119071
V. Ragulin
Institute of Physiologically Active Compounds
Email: tsebrikova@yandex.ru
Россия, Chernogolovka, Moscow oblast
V. Baulin
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry; Institute of Physiologically Active Compounds
Email: tsebrikova@yandex.ru
Россия, Leninskii pr. 31/4, Moscow, 119071; Chernogolovka, Moscow oblast
K. German
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
Email: tsebrikova@yandex.ru
Россия, Leninskii pr. 31/4, Moscow, 119071
A. Malysheva
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Россия, Moscow
O. Klement’eva
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Россия, Moscow
G. Kodina
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Россия, Moscow
A. Larenkov
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Россия, Moscow
E. Lyamtseva
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Россия, Moscow
N. Taratonenkova
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Россия, Moscow
M. Zhukova
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
Email: tsebrikova@yandex.ru
Россия, Leninskii pr. 31/4, Moscow, 119071
A. Tsivadze
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry
Email: tsebrikova@yandex.ru
Россия, Leninskii pr. 31/4, Moscow, 119071
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