Synthesis, Characterization, and Biological Activity of Organotin(IV) Complexes with Schiff Bases
- Authors: Nazneen S.1, Ali S.1, Shahzadi S.1, Shujah S.1
-
Affiliations:
- Department of Chemistry
- Issue: Vol 87, No 12 (2017)
- Pages: 2970-2978
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221794
- DOI: https://doi.org/10.1134/S1070363217120404
- ID: 221794
Cite item
Abstract
The synthesized Schiff base ligands H2L1, N,N'-bis(2-hydroxybenzylidene)1,2-diaminobenzene, and H2L2, N,N'-bis(2-hydroxybenzylidene)hydrazine, reacted with Alk2SnCl2 to give organotin(IV) complexes 1–10. The products were characterized by elemental analysis, FTIR, 1H and 13C NMR, and mass spectrometry. All organotin(IV) derivatives with [O,N,O] donor ligands retained their 5-coordinated geometry in solid state and solutions. Most of synthesized complexes exhibited significant antibacterial activity. Cytotoxicity was also tested by using the brine shrimp (Artemia salina) lethality bioassay.
Keywords
About the authors
S. Nazneen
Department of Chemistry
Email: sairashahzadi@hotmail.com
Pakistan, Islamabad
S. Ali
Department of Chemistry
Author for correspondence.
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
S. Shahzadi
Department of Chemistry; Department of Chemistry
Author for correspondence.
Email: sairashahzadi@hotmail.com
Pakistan, Islamabad, 45320; Faisalabad
S. Shujah
Department of Chemistry
Email: sairashahzadi@hotmail.com
Pakistan, Kohat, KPK, 26000