Synthesis, Characterization, and Biological Activity of Organotin(IV) Complexes with Schiff Bases

Abstract

The synthesized Schiff base ligands H₂L¹, N,N'-bis(2-hydroxybenzylidene)1,2-diaminobenzene, and H₂L², N,N'-bis(2-hydroxybenzylidene)hydrazine, reacted with Alk₂SnCl₂ to give organotin(IV) complexes 1–10. The products were characterized by elemental analysis, FTIR, ¹H and ¹³C NMR, and mass spectrometry. All organotin(IV) derivatives with [O,N,O] donor ligands retained their 5-coordinated geometry in solid state and solutions. Most of synthesized complexes exhibited significant antibacterial activity. Cytotoxicity was also tested by using the brine shrimp (Artemia salina) lethality bioassay.