Email this article Synthesis of Novel 4-[1-(3-Chlorophenyl)-3-(pyren-1-yl)-1H-pyrazol-4-yl]-6-(substituted phenyl)-1,2-dihydro-2-oxo(imino)pyridine-3-carbonitriles
- Authors: Khalifa N.M.1,2, Al-Omar M.A.1, Ali O.M.3
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Affiliations:
- Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy
- Therapeutical Chemistry Department, Pharmaceutical and Drug Industries Division
- Department of Chemistry, Faculty of Medical and Applied Science
- Issue: Vol 87, No 12 (2017)
- Pages: 2933-2936
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221768
- DOI: https://doi.org/10.1134/S1070363217120349
- ID: 221768
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Abstract
A novel compounds of 4,6-diaryl-2-oxo(imino)-1,2-dihydro-pyridine-3-carbonitriles has been synthesized by reaction of 1-(3-chlorophenyl)-3-(pyren-1-yl)-1H-pyrazole-4-carbaldehyde with different 1-(substituted phenyl)ethanones and ethyl cyanoacetate or malononitrile in presence of ammonium acetate. Structure of the newly synthesized compounds was elucidated from chemical and spectroscopic data.
About the authors
N. M. Khalifa
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy; Therapeutical Chemistry Department, Pharmaceutical and Drug Industries Division
Author for correspondence.
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
M. A. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451
O. M. Ali
Department of Chemistry, Faculty of Medical and Applied Science
Email: nagykhalifa@hotmail.com
Saudi Arabia, Taif
