Email this article Modification of Diphenylphosphorylacetic Hydrazide with Thiosemicarbazide and Triazole Units
- Authors: Krutov I.A.1, Gavrilova E.L.1, Burangulova R.N.1, Kornilov S.S.1, Valieva A.A.1, Samigullina A.I.2, Gubaidullin A.T.2, Sinyashin O.G.1,2, Semina I.I.3, Nikitin D.O.3, Plotnikova A.V.3
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Affiliations:
- Kazan National Research Technological University
- A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
- Kazan State Medical University
- Issue: Vol 87, No 12 (2017)
- Pages: 2794-2800
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221683
- DOI: https://doi.org/10.1134/S1070363217120076
- ID: 221683
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Abstract
Thiosemicarbazides of diphenylphosphorylacetic acid and their cyclic derivatives have been synthesized. Functionalization of the obtained 1,2,4-triazole-3-thiones with ethyl 2-bromoacetate at the sulfur atom has been carried out, the obtained esters have been transformed into the corresponding hydrazides via hydrazinolysis. Preliminary pharmacological tests of the synthesized compounds have been performed.
About the authors
I. A. Krutov
Kazan National Research Technological University
Email: gavrilova_elena_@mail.ru
Russian Federation, ul. K. Marksa 68, Kazan, Tatarstan, 420015
E. L. Gavrilova
Kazan National Research Technological University
Author for correspondence.
Email: gavrilova_elena_@mail.ru
Russian Federation, ul. K. Marksa 68, Kazan, Tatarstan, 420015
R. N. Burangulova
Kazan National Research Technological University
Email: gavrilova_elena_@mail.ru
Russian Federation, ul. K. Marksa 68, Kazan, Tatarstan, 420015
S. S. Kornilov
Kazan National Research Technological University
Email: gavrilova_elena_@mail.ru
Russian Federation, ul. K. Marksa 68, Kazan, Tatarstan, 420015
A. A. Valieva
Kazan National Research Technological University
Email: gavrilova_elena_@mail.ru
Russian Federation, ul. K. Marksa 68, Kazan, Tatarstan, 420015
A. I. Samigullina
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: gavrilova_elena_@mail.ru
Russian Federation, Kazan, Tatarstan
A. T. Gubaidullin
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: gavrilova_elena_@mail.ru
Russian Federation, Kazan, Tatarstan
O. G. Sinyashin
Kazan National Research Technological University; A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: gavrilova_elena_@mail.ru
Russian Federation, ul. K. Marksa 68, Kazan, Tatarstan, 420015; Kazan, Tatarstan
I. I. Semina
Kazan State Medical University
Email: gavrilova_elena_@mail.ru
Russian Federation, Kazan, Tatarstan
D. O. Nikitin
Kazan State Medical University
Email: gavrilova_elena_@mail.ru
Russian Federation, Kazan, Tatarstan
A. V. Plotnikova
Kazan State Medical University
Email: gavrilova_elena_@mail.ru
Russian Federation, Kazan, Tatarstan
