Modification of Diphenylphosphorylacetic Hydrazide with Thiosemicarbazide and Triazole Units

I. A. Krutov; E. L. Gavrilova; R. N. Burangulova; S. S. Kornilov; A. A. Valieva; A. I. Samigullina; A. T. Gubaidullin; O. G. Sinyashin; I. I. Semina; D. O. Nikitin; A. V. Plotnikova

doi:10.1134/S1070363217120076

Modification of Diphenylphosphorylacetic Hydrazide with Thiosemicarbazide and Triazole Units

Autores: Krutov I.¹, Gavrilova E.¹, Burangulova R.¹, Kornilov S.¹, Valieva A.¹, Samigullina A.², Gubaidullin A.², Sinyashin O.¹^,2, Semina I.³, Nikitin D.³, Plotnikova A.³
Afiliações:
1. Kazan National Research Technological University
2. A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
3. Kazan State Medical University
Edição: Volume 87, Nº 12 (2017)
Páginas: 2794-2800
Seção: Article
URL: https://journals.rcsi.science/1070-3632/article/view/221683
DOI: https://doi.org/10.1134/S1070363217120076
ID: 221683

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Thiosemicarbazides of diphenylphosphorylacetic acid and their cyclic derivatives have been synthesized. Functionalization of the obtained 1,2,4-triazole-3-thiones with ethyl 2-bromoacetate at the sulfur atom has been carried out, the obtained esters have been transformed into the corresponding hydrazides via hydrazinolysis. Preliminary pharmacological tests of the synthesized compounds have been performed.