Email this article Novel approach to the synthesis of istaroxime
- Authors: Liang G.1, Guo J.1, Jiang R.1
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Affiliations:
- Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy
- Issue: Vol 87, No 11 (2017)
- Pages: 2643-2647
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221599
- DOI: https://doi.org/10.1134/S1070363217110196
- ID: 221599
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Abstract
Istaroxime 1, a novel cardiotonic agent with high efficiency and low toxicity was synthesized from dehydroepiandrosterone 2 using a novel approach that included epoxidation, ring-opening, substitution, and oximation. The new protocol without gas protection was milder than the reported approaches. The overall yield of the method was 24.1%.
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About the authors
G.-P. Liang
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy
Email: trwjiang@jnu.edu.cn
China, Guangzhou, Guangdong, 510632
J.-H. Guo
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy
Email: trwjiang@jnu.edu.cn
China, Guangzhou, Guangdong, 510632
R.-W. Jiang
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy
Author for correspondence.
Email: trwjiang@jnu.edu.cn
China, Guangzhou, Guangdong, 510632
