Мақаланы E-mail арқылы жіберу Novel approach to the synthesis of istaroxime
- Авторлар: Liang G.1, Guo J.1, Jiang R.1
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Мекемелер:
- Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy
- Шығарылым: Том 87, № 11 (2017)
- Беттер: 2643-2647
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221599
- DOI: https://doi.org/10.1134/S1070363217110196
- ID: 221599
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Аннотация
Istaroxime 1, a novel cardiotonic agent with high efficiency and low toxicity was synthesized from dehydroepiandrosterone 2 using a novel approach that included epoxidation, ring-opening, substitution, and oximation. The new protocol without gas protection was milder than the reported approaches. The overall yield of the method was 24.1%.
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Авторлар туралы
G.-P. Liang
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy
Email: trwjiang@jnu.edu.cn
ҚХР, Guangzhou, Guangdong, 510632
J.-H. Guo
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy
Email: trwjiang@jnu.edu.cn
ҚХР, Guangzhou, Guangdong, 510632
R.-W. Jiang
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy
Хат алмасуға жауапты Автор.
Email: trwjiang@jnu.edu.cn
ҚХР, Guangzhou, Guangdong, 510632
