Synthesis and antibacterial activity of novel 4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}-benzohydrazide derivatives


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Abstract

A series of novel 4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}benzohydrazide derivatives were synthesized and evaluated for their antibacterial activity. Most of the compounds demonstrated high activity towards Escherichia coli, Pseudomonas, Staphylococcus aureus, and Bacillus. Structures of all synthesized compounds were confirmed by spectral analysis.

About the authors

T. Giri

Sreenidhi Institute of Science and Technology (Autonomous)

Email: elxnkits@yahoo.co.in
India, Ghatkesar, Hyderabad, Telangana, 501301

G. Sailaja

Sreenidhi Institute of Science and Technology (Autonomous)

Email: elxnkits@yahoo.co.in
India, Ghatkesar, Hyderabad, Telangana, 501301

E. Laxminarayana

Sreenidhi Institute of Science and Technology (Autonomous)

Author for correspondence.
Email: elxnkits@yahoo.co.in
India, Ghatkesar, Hyderabad, Telangana, 501301

M. Thirumala Chary

Jawaharlal Nehru Technological University Hyderabad

Email: elxnkits@yahoo.co.in
India, Hyderabad, Telangana, 500085

M. Ramesh

Jawaharlal Nehru Technological University Kakinada

Email: elxnkits@yahoo.co.in
India, Kakinada, Telangana, 533003


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